Synthesis, antioxidant and antimicrobial activity of carbohydrazones

Aleksandra Božić, Nenad Filipović, Irena Novakovic, Snežana Bjelogrlić, Jasmina Nikolić, Saša Drmanić, Aleksandar Marinković

Abstract


Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound a4 in various dimethylsulphoxide–water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungis, and their activity was discussed in relation to the structure of investigated carbohydrazone. 


Keywords


carbohydrazones; antibacterial; antifungal, antioxidant activity; isomers

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DOI: http://dx.doi.org/10.2298/JSC161220045B

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