Investigation into the potential chemical mechanism of carotenoids pro-oxidant activity with liposomes under UV- irradiation

Dragan Jovan Cvetković, Jelena Stanojević, Milorad Cakić, Dejan Marković

Abstract


This study focuses on the behavior of β-carotene and lutein inside multilamellar liposomes under continuous UV-irradiation. Liposomes were obtained by thin film method and carotenoids (Crts) were incorporated by mixing method at various concentrations (0.005, 0.0075, 0.02, 0.07 and 0.5 mol%). Liposomes formation and presence of Crts inside them were confirmed by SEM microscopy and FT-IR spectroscopy, respectively. The antioxidant/pro-oxidant activity of Crts inside liposomes was determined by Thiobarbituric Acid – Malondialdehyde (TBA-MDA) test. Investigated Crts act more or less unexpected (as pro-oxidants) inside lipid bilayer, interacting with UV-produced lipid radicals and suffering under UV-irradiation in the same time. Their pro-oxidant activity, with liposomes and under UV-irradiation, can be explained by unstable adducts formation in reaction with peroxyl radicals, or by Crts-cation radicals formation via electron transfer mechanism. Such tentatively unexpected behavior of carotenoids should be taken into account in further carotenoids based UV-filters projections in cosmetic formulation for skin protection.


Keywords


β-carotene; lutein; liposomes; UV-irradiation; anti/pro-oxidants

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DOI: http://dx.doi.org/10.2298/JSC170224078C

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