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/Author (Cobeljic, Bozidar and Zivkovic, Marijana and Matic, Ivana and Novakovic, Irena and Sladic, Dusan and Andjelkovic, Katarina and Krstic, Natalija)
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/Title ({Synthesis, characterization and biological activity of Pt\(II\) complexes with steroidal thiosemicarbazones})
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/Subject (In this work, Pt\(II\) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data \(elemental analysis, IR, 1D NMR and 2D NMR, HSQC, HMBC, NOESY, COSY\), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that new steroidal thiosemicarbazone complexes were significantly less cytotoxic than corresponding steroidal thiosemicarbazones. Also, complexes show lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.)
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In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D NMR and 2D NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that new steroidal thiosemicarbazone complexes were significantly less cytotoxic than corresponding steroidal thiosemicarbazones. Also, complexes show lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.
Bozidar Cobeljic
Marijana Zivkovic
Ivana Matic
Irena Novakovic
Dusan Sladic
Katarina Andjelkovic
Natalija Krstic
bibtex/citationkey/Cobeljic2021
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bibtex/journal/Journal of the Serbian Chemical Society
bibtex/month/may
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bibtex/volume/86
10.2298/jsc201211083c
3-oxo-$\alpha$
antimicrobial activity
cytotoxicity
hydrazones
square-planar com-plexes
$\beta$-unsaturated steroids
Serbian Chemical Society
{Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones}
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