Chitosan/sodium dodecyl sulphate microcapsules preparation: Influence of applied method Scientific paper

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Jelena Milinković Budinčić
https://orcid.org/0000-0002-1113-4456
Lidija Petrović
https://orcid.org/0000-0002-9542-9576
Milijana Aleksić
Jadranka Fraj
Ljiljana Đekić
https://orcid.org/0000-0003-0172-5305
Sandra Bučko
https://orcid.org/0000-0001-8752-2116
Jaroslav Katona
https://orcid.org/0000-0003-4593-0554
Ljiljana Spasojević
https://orcid.org/0000-0002-7868-8701
Jelena Ostojić
https://orcid.org/0000-0003-1944-3592
Željana Radonić
https://orcid.org/0009-0009-8561-2391
Mina Bosnić
https://orcid.org/0009-0003-9941-7614

Abstract

This study aims to compare and analyse the synthesis of microcapsules stabilized with chitosan/sodium dodecyl sulphate complex according to emul­sion preparation methods. For this purpose, 20 % oil-in-water emulsions were obtained in two ways: by emulsifying the oil phase in aqueous solution of chito­san and its mixtures with anionic surfactant (“method I”) and by subsequently dropping chitosan into an already prepared emulsion stabilized by anionic surf­actant (“method II”). Good stability, positive zeta potential of the emulsions and uniform droplet size distribution obtained with both methods, enabled the pre­paration of chitosan-based microcapsules which were separated by spray drying and investigated in terms of yield, moisture content, particle mean diameter and size distribution. The results showed a uniform particle size distribution and approximately equal mean diameters of emulsion droplets (≈ 8 µm), i.e., sus­pension particles (≈ 5µm), while the microcapsule yields and moisture content for method I were 15 and 1.14 %, and for method II were 1.2 and 2.85 %, res­pectively. These results indicate that method I may be more suitable for use in the pharmaceutical and food industries for the production of chitosan microcap­sules with oil content. The study confirmed that small variations in preparation can lead to large changes in the microencapsulation process and microcapsule structure.

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How to Cite
[1]
J. Milinković Budinčić, “Chitosan/sodium dodecyl sulphate microcapsules preparation: Influence of applied method: Scientific paper”, J. Serb. Chem. Soc., vol. 90, no. 9, pp. 1105–1117, Oct. 2025.
Section
Polymers

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