Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′-yl]-2H-chromen-5-ols

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Dongamanti Ashok
Rangu Kavitha
Srinivas Gundu
Madderla Sarasija

Abstract

A new series of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′-
-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chal­cones 5aj with hydrazine hydrate in presence of sodium acetate under con­ventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6aj were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6cf and 6i showed promising antimicrobial potency.

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How to Cite
[1]
D. Ashok, R. Kavitha, S. Gundu, and M. Sarasija, “Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′-yl]-2H-chromen-5-ols”, J. Serb. Chem. Soc., vol. 84, no. 3, pp. 237–244, Apr. 2019.
Section
Organic Chemistry
Author Biography

Dongamanti Ashok, Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad- 500 007

Professor in Chemistry

Dept. of Chemistry

Osmania University

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