Synthesis, crystal structure and biological activity of a copper(II) complex with a 4-nitro-3-pyrazolecarboxylic ligand

Milica Kosović, Slađana Novaković, Željko Jaćimović, Nedeljko Latinović, Nada Marković, Tamara Đorđević, Eugen Libowitzky, Gerald Giester

Abstract


The reaction of 4-nitro-3-pyrazolecarboxylic acid and Cu(OAc)2×H2O in ethanol resulted in a new coordination compound [Cu2(4-nitro-3-pzc)2(H2O)6]2H2O (4nitro-3pzc = 4-nitro-3-pyrazolecarboxylate). The com­pound was investigated by means of single-crystal X-ray diffraction and infra­red spectroscopy. The biological activity of the complex was also tested. In the crystal structure of [Cu2(4nitro-3-pzc)2(H2O)6]2H2O, the Cu(II) ion is in a distorted [4+2] octahedral coordination due to the Jan–Teller effect. A survey of the Cambridge Structural Database showed that the octahedral coordination geometry is generally rare for pyrazole-bridged Cu(II) complexes. In the case of Cu(II) complexes with the 3-pyrazolecarboxylato ligands, no complexes with a similar octahedral coordination geometry have been reported. Biological research based on determination of the inhibition effect of the commercial fungicide Cabrio top and the newly synthesized complex on Ph. viticola were performed using the phytosanitary method.


Keywords


Pyrazole; Copper; Coordination complexes; Crystal structure; Infrared spectra; Inhibition effect

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DOI: https://doi.org/10.2298/JSC190724133K

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