Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes

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Published: Dec 3, 2019
DOI: https://doi.org/10.2298/JSC190731091L
Keywords:
cyclic voltammetry square wave voltammetry Au electrode GC electrode IrOX electrode total organic carbon analysis

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Jelena Lović
Institute of Chemistry, Technology and Metallurgy – Department of Electrochemistry, University of Belgrade, Njegoševa 12, 11000 Belgrade
Jelena Lađarević
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade
Dušan Mijin
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade
Milka Jadranin
Institute of Chemistry, Technology and Metallurgy – Department of Chemistry, University of Belgrade, Njegoševa 12, 11000 Belgrade
Slobodan Petrović
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrad
Milka Avramov Ivić
Institute of Chemistry, Technology and Metallurgy – Department of Electrochemistry, University of Belgrade, Njegoševa 12, 11000 Belgrade

Abstract

In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave volta­mmetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corres­ponding N-carbonyl guanidine via oxime intermediate is suggested. The sta­bi­lity of MET was tested under directed stress conditions using IrOx elec­trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me­thyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical pro­cesses at three electrodes were followed by UV spectro­scopy and evaluated by total organic carbon analysis.

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How to Cite
[1]
J. Lović, J. Lađarević, D. Mijin, M. Jadranin, S. Petrović, and M. Avramov Ivić, “Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes”, J. Serb. Chem. Soc., vol. 84, no. 11, pp. 1319–1327, Dec. 2019.
Issue
Vol. 84 No. 11 (2019): In Memoriam Issue Devoted to Prof. Konstantin Popov
Section
In Memoriam Issue Devoted to Prof. Konstantin Popov

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