Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation

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Published: Nov 27, 2020
DOI: https://doi.org/10.2298/JSC191231039P
Keywords:
Carbon-carbon coupling, benzofuran, acetylcholinesterase, Alzheimers disease

Main Article Content

Behjat Pouramiri
Student Research Committee, Jiroft University of Medical Sciences, 76179, Jiroft, Iran
https://orcid.org/0000-0003-0541-8943
Mahboobeh Zahedifar
Department of Chemistry, Faculty of Science, University of Jiroft, 7867161167, Jiroft, Iran
Adileh Ayati
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Farah Pouramiri
Department of Internal Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
Mahdiyeh Ahmadi
Student Research Committee, Jiroft University of Medical Sciences, 76179, Jiroft, Iran

Abstract

A series of biologically active disubstituted benzofuran derivatives (3a–d) have been designed and synthesized via C–H bond activation reaction. The chemical structures of all final compounds were confirmed by spectro­scopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compound 3d moderately inhibited AChE activities with 68.12 % value.

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How to Cite
[1]
B. Pouramiri, M. Zahedifar, A. Ayati, F. Pouramiri, and M. Ahmadi, “Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation”, J. Serb. Chem. Soc., vol. 85, no. 11, pp. 1405–1415, Nov. 2020.
Issue
Vol. 85 No. 11 (2020)
Section
Organic Chemistry

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Author Biography

Behjat Pouramiri, Student Research Committee, Jiroft University of Medical Sciences, 76179, Jiroft, Iran

Organic Chemistry
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