Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C−H bond activation

Behjat Pouramiri, Mahboobeh Zahedifar, Adileh Ayati, Farah Pouramiri, Mahdiyeh Ahmadi

Abstract


A series of biologically active disubstituted benzofuran derivatives (3ad) have been designed and synthesized via C–H bond activation reaction. The chemical structures of all final compounds were confirmed by spectro­scopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compound 3d moderately inhibited AChE activities with 68.12 % value.


Keywords


Carbon-carbon coupling, benzofuran, acetylcholinesterase, Alzheimer’s disease

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DOI: https://doi.org/10.2298/JSC191231039P

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