@article{Stanisavljević_Srećo Zelenović_Popsavin_Rodić_Popsavin_Kojić_2022, place={Belgrade, Serbia}, title={Divergent synthesis and antitumour activity of novel conformationally constrained (–)-muricatacin analogues: Scientific paper}, volume={88}, url={https://www.shd-pub.org.rs/index.php/JSCS/article/view/11924}, DOI={10.2298/JSC220613069S}, abstractNote={<p>Four novel conformationally restricted (–)-muricatacin analogues, bearing a methoxy group at the C-5 position and with an alkoxymethyl group аs the C-7 side chain, have been synthesised and their <em>in vitro</em> antiproliferative activity was evaluated against a panel of seven human tumour cell lines, as well as a single normal cell line. All analogues (<strong>9</strong>–<strong>12</strong>) showed diverse anti­pro­liferative effects against all tested human malignant cell lines, but were devoid of any significant cytotoxicity towards the normal foetal lung fibroblasts (MRC-5). A structure–activity relationship study reveals that the introduction of tetrahydrofuran ring, the replacement of C-8 methylene group in the side chain of muricatacin analogues with the O-8 ether functionality, as well as the length of side chain may be beneficial for the antiproliferative effects of these lactones. All novel analogues were more potent than lead compound, (–)-muri­catacin, against HL-60 cell line.</p>}, number={2}, journal={Journal of the Serbian Chemical Society}, author={Stanisavljević, Slađana and Srećo Zelenović, Bojana and Popsavin, Mirjana and Rodić, Marko and Popsavin, Velimir and Kojić, Vesna}, year={2022}, month={Nov.}, pages={113–121} }