@article{Jeremić_Dinić_Pešić_Stepanović_Novaković_Šegan_Sladić_2018, place={Belgrade, Serbia}, title={Alkylamino and aralkylamino derivatives of avarone and its mimetic as selective agents against non-small cell lung cancer cells, their antibacterial and antifungal potential}, volume={83}, url={https://www.shd-pub.org.rs/index.php/JSCS/article/view/7014}, DOI={10.2298/JSC180627062J}, abstractNote={In this paper, the synthesis of fourteen alkylamino and arylamino derivatives of sesquiterpene quinone avarone and its model compound <em>tert</em>-but­ylquinone is described. Branched, cyclic, allylic and benzylic alkylamino/aryl­amino groups were introduced into the quinone moiety. For all the obtained derivatives, their biological activity and redox properties were studied. The cyto­toxic activity of the synthesized derivatives towards multidrug resistant (MDR) human non-small cell lung carcinoma NCI-H460/R cells, their sensitive counter­part NCI-H460 and human normal keratinocytes (HaCaT) was inves­tigated. The antimicrobial activity towards Gram-positive and Gram-negative bacteria, and fungal cultures was determined. Some of the synthesized deri­vat­ives showed selectivity for cancer cells, including MDR cells. Regarding their cell death ind­uction potential, the most promising compounds were allylamino derivatives, preferentially triggering apoptosis, with high selectivity for cancer cells, inc­luding MDR cells. Several compounds showed promising antimic­ro­bial activity, comparable to those of commercial antibiotic and antimycotic agents.}, number={11}, journal={Journal of the Serbian Chemical Society}, author={Jeremić, Marko and Dinić, Jelena and Pešić, Milica and Stepanović, Marija and Novaković, Irena and Šegan, Dejan and Sladić, Dušan}, year={2018}, month={Dec.}, pages={1193–1207} }