Anticancer activity of Schiff base ligand (E)-4-((5-chloro-2- -hydroxybenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol- -3(2H)-one and its Co(II), Cu(II) and Zn(II) metal complexes Scientific paper
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series of transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and VO(II) have been prepared by using the Schiff base ligand (L) derived from 4-aminoantipyrine and 5-chlorosalicylaldehyde. The structural properties of Schiff base ligand were characterized by mass, FT-IR, UV–Vis, 1H-NMR spectroscopy, etc. Also, metal complexes were studied by P-
-XRD, elemental analysis, thermogravimetric studies along with various biological activities. The micro analytical data revealed that, the metal complexes have 1:1 stoichiometry composition of M:L. Generally, it is observed that prepared metal complexes show better antifungal, antibacterial and anticancer activities than its Schiff base ligand.
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References
M. Cinarli, C. YuksektepeAtaol, E. Cinarli, O. Idil, J. Mol. Struc. 1213 (2020) 128 (http://dx.doi.org/10.1016/j.molstruc.2020.128152)
F. I. Abouzayed, S. M. Emam, S. A. Abouel-Enein, J. Mol. Struc. 1216 (2020) 128 (http://dx.doi.org/10.1016/j.molstruc.2020.128314)
I. E. Leon, J. F. Cadavid-Vargas, A. L. Di Virgilio, S. B. Etcheverry, Curr. Med. Chem. 24 (2017) 2 (http://dx.doi.org/10.2174/0929867323666160824162546)
M. R. Gill, K. A. Vallis, Chem. Soc. Rev. 48 (2019) 540 (https://doi.org/10.1039/C8CS00641E)
A. Bijelic, M. Aureliano, A. Rompe, Angew. Chem. Int. Ed. 58 (2019) 2980(https://doi.org/10.1002/anie.201803868)
U. Ndagi, N. Mhlongo, M. E. Soliman, Drug Des. Dev. Ther. 11 (2017) 599 (https://doi.org/10.2147/DDDT.S119488)
T. Sakaeda, K. Kadoyama, Y. Okuno, Int. J. Med. Sci. 8 (2011) 487 (http://doi.org/10.7150/ijms.8.487)
N. J. Wheate, S. Walker, G. E. Craig, R. Oun, Dalton Trans. 39 (2010) 8113 (https://doi.org/10.1039/C0DT00292E)
E. Tisato, C. Marzano, M. Porchia, M. Pellei, C. Santini, Med. Res. Rev. 30 (2010) 708 (https://doi.org/10.1002/med.20174)
D. Denoyer, S. Masaldan, S. La Fontain, M. A. Cater, Metallomics 7 (2015) 1459 (https://doi.org/10.1039/c5mt00149h)
I. Mohanram, J. Meshram, Hindawi Publishing Corporation ISRN Organic Chemistry, 639392 (2014) (http://dx.doi.org/10.1155/2014/639392)
A A. Fadda, K. M. Elattar. J. Biosci. Med. 3 (2015) 114 (http://dx.doi.org/10.4236/jbm.2015.311015)
G. T. Zitouni, M. Sivaci, F. S. Kilic, K. Erol, Eur. J. Med. Chem. 36 (2001) 685 (https://doi.org/10.1016/S0223-5234(01)01252-1)
S. M. Sondhi, V. K. Sharma, N. Singhal, R. P. Verma, R. Shukla, R. Raghubir, M. P. Dubey, Phosphorous, Sulfur, Silicon Relat. Elem. 156 (2000) 21 (https://doi.org/10.1080/10426500008044991)
H. M. Y. Al-Labban, H. M. Sadiq, A. A. J. Aljanaby. J. Phys.: Conf. Ser. 1294 (2019) 052007 (https://doi.org/10.1088/1742-6596/1294/5/052007)
M. Gowri, B. Saranya, S. Athimoolam, Ind. J. Chem., B 60 (2021) 1110 (http://nopr.niscair.res.in/handle/123456789/58188)
E. S. H. El ashry, L. F. Awad, E. I. Ibrahim, O. Kh. Bdeewy, China J. Chem. 25 (2007) 520 (https://doi.org/10.1002/cjoc.200790107)
A. Fadda, K. M. Elatter, Am. J. Org. Chem. 2 (2012) 52 (http://dx.doi.org/10.5923/j.ajoc.20120203.03)
Y.-X. Zou, X. Feng, Z.-Y. Chu, W.-H. Liu, X.-D. Zhang, J.-B. Ba, Regulat. Toxicol. Pharmacol. 103 (2019) 34 (https://doi.org/10.1016/j.yrtph.2019.01.018)
M. Verleyeu, I. Heulardand, J. M. Gillardin, Pharmacol. Res. 41 (2000) 539 (http://dx.doi.org/10.1006/phrs.1999.0619)
R. K. Mishra, B. G. Thakur, Asian J. Chem. 27 (2015) 860 (http://dx.doi.org/10.14233/ajchem.2015.17144)
Y. N. Bharate, M. A. Sakhare, S. B. Jadhav, S. D. Naikade, Rasayan J. Chem. 14 (2021) 479 (http://dx.doi.org/10.31788/RJC.2021.1416097).
Y. X. Sun, Acta Crystallogr., E 62 (2006) 05858 (http://doi.org/10.1107/S1600536806049348)
B. Anupama, M. Padmaja, C. Gyana Kumari, E-J. Chem. 9 (2012) 389. (http://dx.doi.org/10.1155/2012/291850)
R. Ramesh, S. Maheshwaram, J. Inorg. Biochem. 96 (2003) 457 (https://doi.org/10.1016/S0162-0134(03)00237-X)
S. A. Ali, A. A. Soliman, M. M. Aboaly, R. M. Ramadan, J. Coord. Chem. 55 (2013) 1161 (http://dx.doi.org/10.1080/0095897021000023509)
K. Singh, Y. Kumar, P. Puri, C. Sharma, K. R. Aneja, Arab. J. Chem. 10 (2017) 978 (https://doi.org/10.1016/j.arabjc.2012.12.038)
M. A. Sakhare, S. A. Khillare, M. K. Lande, B. R. Arbad, Adv. Appl. Sci. Res. 4 (2013) 94 (https://www.primescholars.com/articles/synthesis-characterisation-and-antimicrobial-studies-on-laiii-ceiii-andpriii-complexes-with-a-tetraaza-macrocyclic-ligand.pdf)
T. J. Saritha, P. Metilda, J. Saudi Chem. Soc. 25 (2021) 101245 (https://doi.org/10.1016/j.jscs.2021.101245)
P. Jayaseelan, E. Akila, M. Usha Rani, R. Rajavel, J. Saudi Chem. Soc. 20 (2016) 625(http://dx.doi.org/10.1016/j.jscs.2013.07.001)
A. A. S. Al-Hamdani, A. M. Balkhi, A. Falah. S. A. Shaker, J. Chil. Chem. Soc. 60 (2015) 2774 (http://dx.doi.org/10.4067/S0717-97072015000100003)
Y. N. Bharate, K. B. Sakhare, S. A. Surwase, M. A. Sakhare, Heterocycl. Lett. 13 (2023) 45 (https://www.heteroletters.org/issue131/Paper-5.pdf)
A. Aghao, D. Janrao, S. Janrao, M. Farooqui, J. Pharma Res. 5 (2016) 94 (https://jprinfo.com/storage/live/2020-04-05%2000_02_574.Arvind%20Aghao.pdf)
Y. N. Bharate, K. B. Sakhare, S. J. Chavan, M. A. Sakhare, Int. J. Sci. Res. Sci. Tech. 9 (2022) 116 (https://ijsrst.com/IJSRST22291617)
L. K. Dammu, S. K. Nara, V. Venkata, J. Nimmagadda, S. Kalluru., J. Adv. Sci. Res. 14 (2023) 35-39 (https://doi.org/10.55218/JASR.202314105)
L. H. Abdel-Rahman, A. M. Abu-Dief, E. F. Newair, S. K. Hamdan, J. Photochem. Photobiol. 18 (2016) 160 (http://dx.doi.org/10.1016/j.jphotobiol.2016.03.040)
A. M. Abu-Dief, L. A. Nassr, J. Iran. Chem. Soc. 12 (2015) 943 (https://doi.org/10.1007/s13738-014-0557-9)
P. S. Mane, S. G. Shirodkar, B. R. Arbad, T. K. Chondhekar, Ind. J. Chem., A 40 (2001) 648 (http://nopr.niscpr.res.in/handle/123456789/21060)
P. V. Rao, A. V. Narasaiah, Ind. J. Chem., A 42 (2003) 1896 (http://nopr.niscpr.res.in/handle/123456789/20716)c
H. Laila, A. Rahman, A. M. Abu-Dief, R. M. El-Khatib, S. M. Abdel-Fatah, Photochem. Photobiol. 69 (2016) 140 (http://doi/10.1016/j.jphptobiol.2016.06.052).