Breaking news: Empirical formulas, molar masses, biosynthesis reactions and thermodynamic properties of virus particles – Biosynthesis and binding of Omicron JN.1 variant of SARS-CoV-2 Scientific paper
Article Sidebar
Main Article Content
Abstract
Breaking news are usually disturbing. Natural disasters, wars, epidemics, etc., are reported as breaking news. This paper reports a decreased danger of spreading of epidemics caused by the JN.1 variant, since analyses indicate that infectivity of the new variant is decreased compared to most earlier variants, which is confirmed by the number of cases (7500 daily in USA). Moreover, JN.1, despite the great number of mutations, has not been able to achieve the values of Gibbs energy change of biosynthesis (and thus virus multiplication rate) of the Hu-1 wild type. The research shows that infectivity and pathogenicity of the JN.1 variant has not reached worrying size, which means that there is no reason to expect the epidemiologic situation getting worse.
Downloads
Metrics
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Funding data
-
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-47/2023-01/200026
References
H. Wang, X. Li, T. Li, S. Zhang, L. Wang, X. Wu, J. Liu, Eur. J. Clin. Microb. Infect. Dis. 39 (2020) 1629 (https://doi.org/10.1007/s10096-020-03899-4)
Y. Huang, C. Yang, Xf. Xu, W. Xu, S.-W. Liu, Acta Pharmacol. Sin. 41 (2020) 1141 (https://doi.org/10.1038/s41401-020-0485-4)
B. W. Neuman, M. J. Buchmeier, Adv. Vir. Res. 96 (2016) 1 (https://doi.org/10.1016/bs.aivir.2016.08.005)
M. Pal, G. Berhanu, C. Desalegn, V. Kandi, Cureus 12 (2020) e7423 (https://doi.org/10.7759/cureus.7423)
S. Duffy, PLoS Biology 16 (2018) e3000003 (https://doi.org/10.1371/journal.pbio.3000003)
P. V. Markov, M. Ghafari, M. Beer, K. Lythgoe, P. Simmonds, N. I. Stilianakis, A. Katzourakis, Nat Rev Microbiol 21 (2023) 361 (https://doi.org/10.1038/s41579-023-00878-2)
G. Campi, A. Perali, A. Marcelli, A. Bianconi, Sci. Rep. 12 (2022) 18108 (https://doi.org/10.1038/s41598-022-22816-7)
W. T. Harvey, A. M. Carabelli, B. Jackson, R. K. Gupta, E. C. Thomson, E. M. Harrison, C. Ludden, R. Reeve, A. Rambaut, COVID-19 Genomics UK (COG-UK) Consortium, S. J. Peacock, D. L. Robertson, Nat. Rev. Microbiol. 19 (2021) 409 (https://doi.org/10.1038/s41579-021-00573-0)
WHO COVID-19 dashboard, https://data.who.int/dashboards/covid19/cases?n=c (Accessed on Jan. 4, 2024)
E. Wimmer, EMBO Reports 7 (2006) S3 (https://doi.org/10.1038/sj.embor.7400728)
S. K. Thaker, J. Ch’ng, H.R. Christofk, BMC Biol. 17 (2019) 59 (https://doi.org/10.1186/s12915-019-0678-9)
X. Du, Y. Li, Y.L. Xia, S.M. Ai, J. Liang, P. Sang, X.L. Ji, S.Q. Liu, Internat. J. Mol. Sci. 17 (2016) 144 (https://doi.org/10.3390/ijms17020144)
M. Popovic, J. H. Martin, R. J. Head, Heliyon 9 (2023) e17174 (https://doi.org/10.1016/j.heliyon.2023.e17174)
A. V. Pinheiro, P. Baptista, J. C. Lima, Nucl. Acids Res. 36 (2008) e90 (https://doi.org/10.1093/nar/gkn415)
T. Dodd, M. Botto, F. Paul, R. Fernandez-Leiro, M. H. Lamers, I. Ivanov, Nature Commun. 11 (2020) 5379 (https://doi.org/10.1038/s41467-020-19165-2)
W. H. Wang, A. Thitithanyanont, S. F. Wang, Viruses 14 (2022) 1650 (https://doi.org/10.3390/v14081650)
R. D. Cadena-Nava, M. Comas-Garcia, R. F. Garmann, A. L. Rao, C. M. Knobler, W. M. Gelbart, J. Virology 86 (2012) 3318 (https://doi.org/10.1128/JVI.06566-11)
U. Von Stockar, in: Biothermodynamics: the role of thermodynamics in Biochemical Engineering, U. von Stockar, ed., EPFL Press, Lausanne, 2013, pp. 475–534
U. von Stockar, J. Liu, Biochim. Biophys. Acta 1412(1999) 191 (https://doi.org/10.1016/s0005-2728(99)00065-1)
M. Popovic, M. Pantović Pavlović, M. Pavlović, Microb. Risk Anal. 24 (2023) 100263 (https://doi.org/10.1016/j.mran.2023.100263)
M. E. Popović, M. Pantović Pavlović, M. Popović, Microb. Risk Anal. 25 (2023) 100280 (https://doi.org/10.1016/j.mran.2023.100280)
M. Popovic, Comp. Biol. Chem. 96 (2022) 107621 (https://doi.org/10.1016/j.compbiolchem.2022.107621)
M. Popovic, V. Tadić, M. Mihailović, J. Biomol. Struct. Dyn. (2023) (https://doi.org/10.1080/07391102.2023.2256880)
S. A. Patel, L. E. Erickson, Biotechnol. Bioeng. 23 (1981) 2051 (https://doi.org/10.1002/bit.260230910)
E. H. Battley, Thermochim. Acta 309 (1998) 17 (https://doi.org/10.1016/S0040-6031(97)00357-2)
E. H. Battley, Thermochim. Acta 326 (1999) 7 (https://doi.org/10.1016/S0040-6031(98)00584-X)
M. Popovic, Vaccines 10 (2022) 2112 (https://doi.org/10.3390/vaccines10122112)
M. Popovic, Microb. Risk Anal. 22 (2022) 100236 https://doi.org/10.1016/j.mran.2022.100236
M. Popovic, Thermal Sci. 26 (2022) 4855 (https://doi.org/10.2298/TSCI220524142P)
M. Popovic, M. Popovic, G. Šekularac, Microb. Risk Anal. 25 (2023) 100281 (https://doi.org/10.1016/j.mran.2023.100281)
B. Şimşek, M. Özilgen, F. Ş. Utku, Energy Storage 4 (2021) e298 (https://doi.org/10.1002/est2.298)
M. E. Popovic, M. Mihailović, S. Pavlović, Microb. Risk Anal. 25 (2023) 100273 (https://doi.org/10.1016/j.mran.2023.100273)
M. S. Maginnis, J. Mol. Biol. 430 (2018) 2590 (https://doi.org/10.1016/j.jmb.2018.06.024)
M. Popovic, Microbiol. Res. 270 (2023) 127337 (https://doi.org/10.1016/j.micres.2023.127337)
P. Gale, Microb. Risk Anal. 15 (2020) 100104 (https://doi.org/10.1016/j.mran.2020.100104)
P. Gale, Microb. Risk Anal. 16 (2020) 100140 (https://doi.org/10.1016/j.mran.2020.100140)
R. J. Head, E. R. Lumbers, B. Jarrott, F. Tretter, G. Smith, K. G. Pringle, S. Islam, J. H. Martin, Pharmacol. Res. Persp. 10 (2022) e00922 (https://doi.org/10.1002/prp2.922)
U. Lucia, G. Grisolia, T. S. Deisboeck, Atti Accad. Peloritana Pericolanti 99 (2021) A3 (https://doi.org/10.1478/AAPP.992A3)
M. Özilgen, B. Yilmaz, Int. J. Energy Res. 45 (2021) 1157 (https://doi.org/10.1002/er.5883)
U. Lucia, T. S. Deisboeck, G. Grisolia, Front. Phys. 8 (2020) 274 (https://doi.org/10.3389/fphy.2020.00274)
S. Khare, C. Gurry, L. Freitas, M. B. Schultz, G. Bach, A. Diallo, N. Akite, J. Ho, R. T. C. Lee, W. Yeo, GISAID Core Curation Team, S. Maurer-Stroh, China CDC Weekly 3 (2021) 1049 (https://doi.org/10.46234/ccdcw2021.255)
E. W. Sayers, E. E. Bolton, J. R. Brister, K. Canese, J. Chan, D. C. Comeau, R. Connor, K. Funk, C. Kelly, S. Kim, T. Madej, A. Marchler-Bauer, C. Lanczycki, S. Lathrop, Z. Lu, F. Thibaud-Nissen, T. Murphy, L. Phan, Y. Skripchenko, T. Tse, J. Wang, R. Williams, B. W Trawick, K. D Pruitt, S.T. Sherry, Nucl. Acids Res. 50 (2022) D20 (https://doi.org/10.1093/nar/gkab1112)
S. Yang, Y. Yu, Y. Xu, F. Jian, W. Song, A. Yisimayi, P. Wang, J. Wang, J. Liu, L. Yu, X. Niu, J. Wang, Y. Wang, F. Shao, R. Jin, Y. Wang, Yunlong, Lancet Infect. Diseases (2023) S1473 (https://doi.org/10.1016/S1473-3099(23)00744-2)
P.W. Atkins, J. de Paula, Physical Chemistry for the Life Sciences, 2nd ed., W. H. Freeman and Company, London, 2011 (ISBN-13: 978-1429231145)
M. Popovic, Microb. Risk Anal. 24 (2023) 100260 (https://doi.org/10.1016/j.mran.2023.100260)
S. Riedel, J.A. Hobden, S. Miller, S.A. Morse, T.A. Mietzner, B. Detrick, T.G. Mitchell, J.A. Sakanari, P. Hotez, R. Mejia, Jawetz, Melnick and Adelberg’s Medical Microbiology, 28th ed., McGraw-Hill, New York, 2019 (ISBN-13: 978-1260012026)
End of the Federal COVID-19 Public Health Emergency (PHE) Declaration, https://www.cdc.gov/coronavirus/2019-ncov/your-health/end-of-phe.html (Accessed on Jan. 7, 2024)
M. Popovic, Microb. Risk Anal. 22 (2022) 100217 (https://doi.org/10.1016/j.mran.2022.100217)
C. Degueldre, Talanta 228 (2021) 122211 (https://doi.org/10.1016/j.talanta.2021.122211)
M. A. Martín-Acebes, J.C. Saiz, World J. Virol. 1 (2012) 51 (https://doi.org/10.5501/wjv.v1.i2.51)
M. M. Mehndiratta, P. Mehndiratta, R. Pande, Neurohospitalist 4 (2014) 223 (https://doi.org/10.1177/1941874414533352)
M. Popovic, Virology 575 (2022) 36 (https://doi.org/10.1016/j.virol.2022.08.009)
M. Popovic, Microb. Risk Anal. 22 (2022) 100232 (https://doi.org/10.1016/j.mran.2022.100232)
J.A. Tetro, Microbes Infect. 22 (2020) 72 (https://doi.org/10.1016/j.micinf.2020.02.006)
M. E. Popović, G. Šekularac, M. Mihailović, Microb. Risk Anal. 26 (2024) 100291 (https://doi.org/10.1016/j.mran.2024.100291).