DNA/bovine serum albumin interaction studies and immunomodulatory effects of dinuclear platinum(II) complex with aromatic 1,5-naphthyridine bridging ligand Scientific paper
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Abstract
The DNA and bovine serum albumin binding evaluation of the dinuclear platinum(II) complex, [{PtCl(NH3)2}2(μ-1,5-nphe)](ClO4)2 (1,5-nphe is the bridging 1,5-naphthyridine ligand) was investigated by UV–Vis and fluorescence emission spectroscopy. Influence of platinum(II) complex on immune response was also estimated. Peritoneal splenocytes isolated from BALB/c mice were treated with Concanavalin A (ConA) and platinum(II) complex. Concentrations of IFN-γ, IL-1β, IL-17, TNF-α and IL-10 were measured and immunophenotyping was performed. Results showed notable immunomodulatory effects. Pt(II) complex has an inhibitory effect on the release of proinflammatory cytokines in ConA activated splenocytes and CD3+ T cells..
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
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Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-9/2021-14/200026;451-03-9/2021-14/200122;451-03-9/2021-14/200111 -
Serbian Academy of Sciences and Arts
Grant numbers F128 -
Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu
Grant numbers JP02/20
References
C. Johnstone, K. Suntharalingam, S. J. Lippard, Chem. Rev. 116 (2016) 3436 (https://doi.org/10.1021/acs.chemrev.5b00597)
N. J. Wheate, S. Walker, G. E. Craig, R. Oun, Dalton Trans. 39 (2010) 8113 (https://doi.org/10.1039/C0DT00292E)
L. Kelland, Nat. Rev. Cancer 7 (2007) 573 (https://doi.org/10.1038/nrc2167 )
E. R. Jamieson, S. J. Lippard, Chem Rev. 99 (1999) 2467 (https://doi.org/10.1021/cr980421n)
J. Reedijk, Chem Rev. 99 (1999) 2499 (https://doi.org/10.1021/cr980422f)
I. S. Mfouo-Tynga, L. D. Dias, N. M. Inada, C. Kurachi, Photodiagnosis Photodyn. Ther. 34 (2021) 102091 (https://doi.org/10.1016/j.pdpdt.2020.102091)
Z. F. Liu, H. Wang, Z. Zhang, J. Inorg. Biochem. 222 (2021) 111508 (https://doi.org/10.1016/j.jinorgbio.2021.111508)
Y. J. Wang, X. Shi, H. Fang, Z. Han, H. Yuan, Z. Zhu, L. Dong, Z. Guo, X. Wang, J. Med. Chem. 65 (2022) 7786 (https://doi.org/10.1021/acs.jmedchem.2c00141)
X. Han, X. Gao, Curr. Med. Chem. 8 (2001) 551 http://dx.doi.org/10.2174/0929867003373337)
S. Neidle, C. M. Nunn, Nature Prod. Rep. 15 (1998) 1 (https://doi.org/10.1039/A815001Y)
G. Bischoff, S. Hoffmann, Curr. Med. Chem. 9 (2002) 312 (https://doi.org/10.2174/0929867023371085)
J. N. Lisgarten, M. Coll, J. Portugal, C. W. Wright, J. Aymami, Nature Struct. Biol. 9 (2002) 57 (https://doi.org/10.1038/nsb729)
N. Farrell, S. Spinelli, in Uses of Inorganic Chemistry in Medicine, N. Farrell, Ed., Royal Society of Chemistry, London, 1999, pp. 124–134 (https://doi.org/10.1039/9781847552242-00124)
B. Konovalov, M. D. Živković, J. Z. Milovanović, D. B. Djordjević, A. N. Arsenijević, I. R. Vasić, G. V. Janjić, A. Franich, D. Manojlović, S. Skrivanj, M. Z. Milovanović, M. I. Djuran, S. Rajković, Dalton Trans. 47 (2018) 15091 (https://doi.org/10.1039/C8DT01946K)
I. Stanisavljević, M. Živković, S. Rajković, M. Obradovic, M. Jurisevic, S. Pavlovic, B. Simovic Markovic, N. Gajovic, I. Corovic, M. Jocic, A. Kostic, I. Jovanovic, Kragujevac J. Sci. 46 (2024) 73 (https://doi.org/10.5937/kgjsci2400003s )
A. A. Recio Despaigne, J. G. Da Silva, P. R. da Costa, R. G. dos Santos, H. Beraldo, Molecules 19 (2014) 17202 (https://doi.org/10.3390/molecules191117202)
S. Dhar, M. Nethaji, A. R. Chakravarty, J. Inorg. Biochem. 99 (2005) 805 (https://doi.org/10.1016/j.jinorgbio.2004.12.014)
B. Konovalov, A. A. Franich, M. Jovanović, M. Jurisević, N. Gajović, M. Jovanović, N. Arsenijević, V. Maric, I. Jovanović, M.D. Živković, S. Rajković, Appl. Organomet. Chem. 35 (2021) e6112 (https://doi.org/10.1002/aoc.6112)
P. Smolenski, C. Pettinari, F. Marchetti, M. F. Guedes da Silva, G. Lupidi, G. V. Badillo Patzmay, D. Petrelli, L. A. Vitali, A. J. Pombeiro, Inorg. Chem. 54 (2015) 434 (https://doi.org/10.1021/ic501855k)
J. R. Lakowicz, Principles of Fluorescence Spectroscopy, Springer, New York, 2006
(e-ISBN-13: 978-0-387-46312-4)
M. Kumari, J. K. Maurya, U. K. Singh, A. B. Khan, M. Ali, P. Singh, R. Patel, Spectrochim. Acta, A 124 (2014) 349 (https://doi.org/10.1016/j.saa.2014.01.012)
P. Kumar, S. Gorai, M. K. Santra, B. Mondal, D. Manna, Dalton Trans. 41 (2012) 7573 (https://doi.org/10.1039/C2DT30232B)
M. Idowu, E. Lamprecht, T. Nyokong, J. Photochem. Photobiol., A 198 (2008) 7 (https://doi.org/10.1016/j.jphotochem.2008.02.008)
D. Ćoćić, S. Jovanović, M. Nišavić, D. Baskić, D. Todorović, S. Popović, Ž. D. Bugarčić, B. Petrović, J. Inorg. Biochem. 175 (2017) 67 (https://doi.org/10.1016/j.jinorgbio.2017.07.009)
A. R. Timerbaev, C. G. Hartinger, S. S. Aleksenko, B. K. Keppler, Chem. Rev. 106 (2006) 2224 (https://doi.org/10.1021/cr040704h)
E. Rutkowska, K. Pajak, K. Jozwiak, Acta Pol. Pharm. 70 (2013) 3 (PMID: 23610954)
Y. Ando, C. Yasuoka, T. Mishima, T. Ikematsu, T. Uede, T. Matsunaga, M. Inobe, In Vitro Cell. Dev. Biol.-Animal 50 (2014) 313 (https://doi.org/10.1007/s11626-013-9705-2)
D. Boraschi, Front. Immunol. 13 (2022) 872155 (https://doi.org/10.3389/fimmu.2022.872155)
H. T. Idriss, J. H. Naismith, Microsc. Res. Tech. 50 (2000) 184 (https://doi.org/10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H)
A. Halimi, N. Mortazavi, A. Memarian, M. Zahedi, F. Niknejad, A. Sohrabi, S. J. Sarraf, BMC Endocr. Disord. 22 (2022) 296 (https://doi.org/10.1186/s12902-022-01217-x)
S. S. Iyer, G. Cheng, Crit. Rev. Immunol. 32 (2012) 23 (https://doi.org/10.1615/critrevimmunol.v32.i1.30)
S. Biswas, K. Bieber, R. A. Manz, Front. Immunol. 13 (2022) 970906 (https://doi.org/10.3389/fimmu.2022.970906)
A. P. Menon, B. Moreno, D. Meraviglia-Crivelli, F. Nonatelli, H. Villanueva, M. Barainka, A. Zheleva, H. M. van Santen, F. Pastor, Cancers 15 (2023) 1189 (https://doi.org/10.3390/cancers15041189)
N. Al-Rajhi, H. Soudy, S. A. Ahmed, T. Elhassan, S. F. Mohammed, H. A. Khoja, H. Ghebeh, BMC Cancer 20 (2020) 240 (https://doi.org/10.1186/s12885-020-06757-w)
D. Cibrián, F. Sánchez-Madrid, Eur. J. Immunol. 47 (2017) 946 (https://doi.org/10.1002/eji.201646837).