Differential pulse voltammetric assay of atorvastatin in tablets using an unmodified glassy carbon electrode
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Abstract
A differential pulse voltammetric (DPV) procedure was evaluated for the determination of atorvastatin (ATOR) in tablet formulations using an unmodified glassy carbon electrode (GCE). The electrochemical behavior of ATOR was examined by cyclic voltammetry in Britton–Robinson buffer, and pH 4 was selected for further measurements because it provided a well-defined irreversible oxidation signal at approximately +1.05 V vs. Ag/AgCl/3 M KCl. The scan-rate study supported a predominantly diffusion-controlled oxidation process. Under optimized DPV conditions, the anodic peak current was linear in the ATOR concentration range from 0.05 to 0.84 µM. The limit of detection was 13 nM, and the repeatability was 6.4 % for twelve consecutive measurements of 0.11 µM ATOR. The method was applied to commercial Torvacard Novum tablets using the standard addition method, with recoveries from 101.2 to 103.5 %. The procedure is intended as a simple low-concentration assay for tablet extracts after appropriate dilution, without electrode modification, preconcentration or complex sample preparation.
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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
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Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
Grant numbers VEGA No. 1/0036/24 -
Agentúra na Podporu Výskumu a Vývoja
Grant numbers APVV-23-0066
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