Highly sensitive, non-enzymatic and precious metal-free electrochemical glucose sensor based on a Ni–Cu/TiO2 modified glassy carbon electrode

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Abdul Raziq
Muhammad Tariq
Riaz Hussain
Muhammad H. Mahmood
Inam Ullah
Jahanjeer Khan
Mamriz Mohammad


Herein, a facile one step synthesis of Ni–Cu supported on TiO2 alloy nanoparticles through the polyol method, which reflect high catalytic perform­ance in enzymeless electrochemical glucose sensing and applied onto glassy carbon, is reported. The morpho­logy imaging and physical properties of the Ni–Cu/TiO2 nanocomposite were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, and energy dispersive X-ray spectroscopy (EDS). The electro­chemical studies/characterizations of glucose oxidation were realised in a basic medium and the new sensor was found to be a better electrochemical glucose sensor than Ni/TiO2/Ti and CuO/TiO2/Ti modified electrodes. The fabricated sensor was highly sensitive (719.9 µA mM-1 cm-2), had a wide linear range (from 0.1 to 6 mM), selective and tolerant towards endogenous species, such as ascorbic acid, uric acid, acetaminophen and sodium chloride.


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A. Raziq, “Highly sensitive, non-enzymatic and precious metal-free electrochemical glucose sensor based on a Ni–Cu/TiO2 modified glassy carbon electrode”, J. Serb. Chem. Soc., vol. 83, no. 6, pp. 733–744, Jul. 2018.
Analytical Chemistry


L. Rong, C. Yang, Q. Qian, X. Xia, Talanta 72 (2007) 819

X. Zhang, H. Ju, J. Wang, J. Wang, Electrochemical glucose biosensors, in Electro-chemical sensors, biosensors and their biomedical applications, Academic Press, New York, 2008, p. 57

S. A. Zaidi, J. H. Shin, Talanta 149 (2016) 30

M. M. Rahman, A. J. S. Ahammad, J.-H. Jin, S. J. Ahn, J.-J. Lee, Sensors 10 (2010) 4855

M. Q. Guo, H. S. Hong, X. N. Tang, H. D. Fang, X. H. Xu, Electrochim. Acta 63 (2012) 1

S. Cherevko, C.-H. Chung, Sensors Actuators, B: Chem. 142 (2009) 216

H. Bai, M. Han, Y. Du, J. Bao, Z. Dai, Chem. Commun. (Camb.) 46 (2010) 1739

S. Ben Aoun, G. S. Bang, T. Koga, Y. Nonaka, T. Sotomura, I. Taniguchi, Electrochem. Commun. 5 (2003) 317

J. Wang, D. F. Thomas, A. Chen, Anal. Chem. 80 (2008) 997

K. Lee, S. Cho, S. Heum Park, A. J. Heeger, C.-W. Lee, S.-H. Lee, Nature 441 (2006) 65

Z. Zeng, X. Zhou, X. Huang, Z. Wang, Y. Yang, Q. Zhang, F. Boey, H. Zhang, Analyst 135 (2010) 1726

X. Zhang, G. Wang, Y. Huang, L. Yu, B. Fang, Micro Nano Lett. 7 (2012) 168

H. Gao, F. Xiao, C. B. Ching, H. Duan, ACS Appl. Mater. Interfaces 3 (2011) 3049

E. Turkušić, K. Kalcher, K. Schachl, A. Komersova, M. Bartos, H. Moderegger, I. Svancara, K. Vytras, Anal. Lett. 15 (2001) 2633

T. G. S. Babu, T. Ramachandran, Electrochim. Acta 55 (2010) 1612

Z.-D. Gao, Y. Han, Y. Wang, J. Xu, Y.-Y. Song, Sci. Rep. 3 (2013) 3323

C. Zhou, L. Xu, J. Song, R. Xing, S. Xu, D. Liu, H. Song, Sci. Rep. 4 (2015) 7382

R. Ding, J. Liu, J. Jiang, F. Wu, J. Zhu, X. Huang, Catal. Sci. Technol. 1 (2011) 1406

X.-K. Tian, X.-Y. Zhao, L. Zhang, C. Yang, Z.-B. Pi, S.-X. Zhang, Nanotechnology 19 (2008) 215711

W. A. Badawy, K. M. Ismail, A. M. Fathi, Electrochim. Acta 50 (2005) 3603

S. Tong, Y. Xu, Z. Zhang, W. Song, J. Phys. Chem. C 114 (2010) 20925

H. Li, C.-Y. Guo, C.-L. Xu, Biosens. Bioelectron. 63 (2015) 339

H. Fang, M. Wen, H. Chen, Q. Wu, W. Li, Nanoscale 8 (2015) 536

K. Thamaphat, P. Limsuwan, B. Ngotawornchai, Nat. Sci. 42 (2008) 357

E. Nurlaela, F. K. Chong, B. K. Dutta, N. Riaz, Chem. Eng. (2010) 1

N. Riaz, F. K. Chong, Z. B. Man, M. S. Khan, B. K. Dutta, Ind. Eng. Chem. Res. 52 (2013) 4491

M. R. Morales, B. P. Barbero, L. E. Cadús, Appl. Catal., B: Environ. 67 (2006) 229

I.-H. Yeo, D. C. Johnson, J. Electroanal. Chem. 495 (2001) 110

P. Luo, S. V. Prabhu, R. P. Baldwin, Anal. Chem. 62 (1990) 752

P. Druska, H.-H. Strehblow, Corros. Sci. 38 (1996) 1369

G. Wang, X. He, L. Wang, A. Gu, Y. Huang, B. Fang, B. Geng, X. Zhang, Microchim. Acta 180 (2013) 161

S. Park, T. D. Chung, H. C. Kim, Anal. Chem. 75 (2003) 3046

J. Yuan, K. Wang, X. Xia, Adv. Funct. Mater. 15 (2005) 803

M. Gougis, Développement De Capteurs Électrochimiques Non-Enzymatiques Pour La Gestion Du Diabète, http://espace.inrs.ca/id/eprint/2631 (accessed on December 12, 2017)

C. Wang, L. Yin, L. Zhang, R. Gao, J. Phys. Chem. 114 (2010) 4408

S. Luo, F. Su, C. Liu, J. Li, R. Liu, Y. Xiao, Y. Li, X. Liu, Q. Cai, Talanta 86 (2011) 157.

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