Hybrid mesoporous silica with controlled drug release

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Published: Oct 6, 2019
DOI: https://doi.org/10.2298/JSC181109009A
Keywords:
sol–gel process ketoprofen hybrid material SAXS

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Laszlo Almasy
State Key Laboratory of Environment-Friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010 and Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, POB 49 Budapest 1525, Hungary
https://orcid.org/0000-0001-5750-5788
Ana-Maria Putz
Institute of Chemistry Timisoara of Romanian Academy, Bv. Mihai Viteazul, No. 24, RO-300223, Timisoara
https://orcid.org/0000-0001-9349-4721
Qiang Tian
State Key Laboratory of Environment-Friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010
https://orcid.org/0000-0002-9811-4262
Gennady P. Kopitsa
Institute of Silicate Chemistry of RAS, nab. Makarova 2, 199034 St. Petersburg and Petersburg Nuclear Physics Institute, PNPI 1, Orlova roscha mcr., Gatchina, Leningrad region, 188300
https://orcid.org/0000-0002-0525-2480
Tamara V. Khamova
Petersburg Nuclear Physics Institute, PNPI 1, Orlova roscha mcr., Gatchina, Leningrad region, 188300
https://orcid.org/0000-0003-4302-3520
Reka Barabas
Babeș-Bolyai University, Faculty of Chemistry and Chemical Engineering, Department of Chemistry and Chemical Engineering of Hungarian Line of Study, Arany Janos Str. No. 11, RO-400028, Cluj-Napoca
https://orcid.org/0000-0001-6730-084X
Melinda Rigo
Babeș-Bolyai University, Faculty of Chemistry and Chemical Engineering, Department of Chemistry and Chemical Engineering of Hungarian Line of Study, Arany Janos Str. No. 11, RO-400028, Cluj-Napoca
Attila Bota
Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest 1519 Budapest, POB 286, Budapest-1117
https://orcid.org/0000-0002-8636-1426
Andras Wacha
Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest 1519 Budapest, POB 286, Budapest-1117
https://orcid.org/0000-0002-9609-0893
Marius C. Mirica
National Institute for Research and Development in Electrochemistry and Condensed Matter, Dr. Aurel Păunescu Podeanu Str. No. 144, RO-300569, Timisoara
Bogdan O. Taranu
8National Institute for Research and Development in Electrochemistry and Condensed Matter, Dr. Aurel Păunescu Podeanu Str. No. 144, RO-300569, Timisoara,
https://orcid.org/0000-0003-1515-8065
Cecilia Savii
Institute of Chemistry Timisoara of Romanian Academy, Bv. Mihai Viteazul, No. 24, RO-300223, Timisoara
https://orcid.org/0000-0001-7036-334X

Abstract

The mesoporous silica particles were prepared by the sol–gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyl­triethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammoni­um bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated pre­cursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.

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How to Cite
[1]
L. Almasy, “Hybrid mesoporous silica with controlled drug release”, J. Serb. Chem. Soc., vol. 84, no. 9, pp. 1027–1039, Oct. 2019.
Issue
Vol. 84 No. 9 (2019)
Section
Materials

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