Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A (Short Communication)

Filip Bihelovic, Zorana Ferjancic, Zlatko Joncev


Two new analogues of alstoscholarisine A, containing phenyl or butyl substituent at C-19 position, have been prepared in racemic form from the known skatole derivative. Syntheses of these compounds were accomplished in 13 steps, with a late-stage formation of the C-19 stereocenter. These derivatives are expected to have significantly changed biological activity, compared to alstoscholarisine A – a potent neuroactive natural product.


Alkaloids; neuronal stem cells; Alstonia scholaris

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