Synthesis and process optimization of Boscalid by catalyst Pd-PEPPSI-IPrDtBu-An

Authors

  • Jian Xu School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, Guangdong Province P. R. China https://orcid.org/0000-0002-3695-5963
  • Xiao-Bing Lan School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, Guangdong Province P. R. China
  • Lin-Jian Xia School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, Guangdong Province P. R. China
  • Yi Yang School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, Guangdong Province P. R. China
  • Gao Cao School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, Guangdong Province P. R. China

DOI:

https://doi.org/10.2298/JSC200330003X

Keywords:

Boscalid, suzuki reaction, Pd-PEPPSI-IPrDtBu-An, synthesis

Abstract

The purpose of this research was to reduce the amount of noble metal palladium catalyst and improve the catalytic performance in the Suzuki-Miyaura cross-coupling reaction, which is the key step in the synthesis of Boscalid. Taking o-bromonitrobenzene and p-chlorophenylboronic acid as raw materials, three kinds of Pd-PEPPSI-IPr catalysts were synthesized and employed in the Suzuki reaction, and then the biaryl product was subjected to reduction and condensation reaction to prepare Boscalid. Under optimal reaction conditions, the result showed that the catalytic system exhibits highest catalytic efficiency under aerobic conditions, giving the 2-(4-chlorophenyl)nitrobenzene over 99 % yield. Moreover, the Pd-PEPPSI-IPrDtBu-An catalyst was minimized to 0.01mol%. The synthesis process was mild, the post-treatment was simple, and the production cost was reduced which makes it suitable for industrial production.

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Graphical Apstract

Published

2021-01-15

How to Cite

[1]
J. Xu, X.-B. Lan, L.-J. Xia, Y. Yang, and G. Cao, “Synthesis and process optimization of Boscalid by catalyst Pd-PEPPSI-IPrDtBu-An”, J. Serb. Chem. Soc., Jan. 2021.

Issue

Section

Organic Chemistry