Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride Scientific paper

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Chetana Deoghare
https://orcid.org/0000-0003-2819-9720
Shruti Balaji
https://orcid.org/0000-0002-4589-5683
Savitha Dhandapani
https://orcid.org/0000-0002-9177-6546
Honey Srivastava
https://orcid.org/0000-0002-0696-675X
Anasuya Ganguly
https://orcid.org/0000-0002-4003-4462
Rashmi Chauhan
https://orcid.org/0000-0003-2998-2311

Abstract

This paper reports the synthesis and characterization of monomers itaconic anhydride (IA) and tri-O-acetyl-d-glucal (TAG) as well as 4,6-di-O-acetyl-d-glucal (PSG). The homopolymers and copolymers of IA and TAG were synthesized via free radical copolymerization in bulk, using azobisiso­but­yronitrile as an initiator with different feed ratios of monomers. Their struc­tural, molecular and thermal characterization was done using 1H-NMR spectro­scopy, gel permeation chromatography and differential scanning calorimetry, respectively. The glass transition temperature (Tg) of copolymers was found in the range of 139–145 °C. The highest Tg was found for IA–TAG2 copolymers, whereas IA–TAG4 copolymer showed lowest Tg. The molecular weight of the copolymers was in the range 5157–5499 g mol-1. The monomer TAG under­goes Ferrier rearrangement in water to give PSG. The antimicrobial activity of IA, TAG, PSG and IA–TAG copolymers was studied using the minimum mic­ro­bicidal concentration-broth dilution method. TAG, IA and PSG, as well as homopolymer and copolymers of IA and TAG are excellent antimicrobial agents.

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How to Cite
[1]
C. Deoghare, S. Balaji, S. Dhandapani, H. Srivastava, A. Ganguly, and R. Chauhan, “Antimicrobial and anticancer activities of copolymers of tri-O-acetyl-D-glucal and itaconic anhydride: Scientific paper”, J. Serb. Chem. Soc., vol. 87, no. 5, pp. 629–640, May 2022.
Section
Polymers

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