Biochanin A formulation with electrospun Poly(vinylpyrrolidone) fibers and possible applications

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Published: Feb 24, 2026
DOI: https://doi.org/10.2298/JSC251125007G
Keywords:
polymer, drug delivery, carriers, electrospinning, phytoestrogen

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Ivana Gajić
Faculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia
Sanja Stojanović
Department of Biology and Human Genetics and Department for Cell and Tissue Engineering, Faculty of Medicine, University of Niš, Serbia
Stevo Najman
Department of Biology and Human Genetics and Department for Cell and Tissue Engineering, Faculty of Medicine, University of Niš, Serbia
Ana Dinić
Faculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia
https://orcid.org/0000-0003-3119-033X
Maja Urošević
Faculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia
Vesna Nikolić
Faculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia
Ljubisa B. Nikolic
Faculty of Technology, University of Niš, Bulevar oslobodjenja 124, 16000 Leskovac, Serbia
https://orcid.org/0000-0003-2886-6618

Abstract

The aim of this paper is to examine the possibility of using electrospun poly(vinylpyrrolidone) (PVP) fibers as a carrier of the phytoestrogen biochanin A (BCA). PVP fibers were prepared with different BCA content by using electrospinning method at specific process parameters. Produced electrospun PVP-BCA fibers were characterized by chemical, physical-mechanical and biological methods. SEM, DSC and FTIR analyzes showed that there are no strong interactions between PVP and BCA molecules, neither thermal changes in tested temperature range (50 - 250°C) and that equal distribution of BCA in the PVP electrospun fibers was achieved. Physico-mechanical tests showed that the physical properties and wetting angle of PVP change in the presence of BCA. Testing of electrospun PVP fibres with and without BCA on L929 fibroblasts in direct contact assay in vitro revealed a significant effect on proliferation and migration of fibroblasts. Biological tests confirmed that the system of electrospun PVP-BCA fibers can become suitable for the treatment of complicated wounds, where in the first stage of treatment the damaged tissue should be removed by the activity of electrospun PVP-BCA fibers. Another possibility of using electrospun PVP-BCA fibers is for the treatment of facial skin for the exfoliation intent.

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[1]
I. Gajić, “Biochanin A formulation with electrospun Poly(vinylpyrrolidone) fibers and possible applications”, J. Serb. Chem. Soc., Feb. 2026.
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Polymers
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