Microwave assisted synthesis of 2-(2-(Tetrazolo[1,5-a]quinolin-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl) substituted phenols and evaluation of their antimicrobial activity

Dongamanti Ashok; Velagapuri Hanumantha Rao; Rangu Kavitha

doi:10.2298/10.2298/JSC150504041A

PDF (1,039 kB) Supplementary Material (2.10 MB)

Published: Sep 1, 2016

DOI: https://doi.org/10.2298/10.2298/JSC150504041A

Keywords:

Antimicrobial activity benzodiazepines chalcones Michael addition microwave irradiation tetrazolo quinoline aldehyde.

Dongamanti Ashok

Department of Chemistry, Osmania University, Hyderabad-500 007, India

Velagapuri Hanumantha Rao

Department of Chemistry, Osmania University, Hyderabad-500 007, India

Rangu Kavitha

Department of Chemistry, Osmania University, Hyderabad-500 007, India

Abstract

A series of new benzodiazepines 4a-h have been synthesized by Michael addition of chalcones 3a-h with o-phenylenediamine (OPDA) in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized benzodiazepines 4a-h have been established on the basis of IR, ¹H & ¹³C NMR and mass spectral data and tested for antimicrobial activity.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

How to Cite

[1]

D. Ashok, V. H. Rao, and R. Kavitha, “Microwave assisted synthesis of 2-(2-(Tetrazolo[1,5-a]quinolin-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl) substituted phenols and evaluation of their antimicrobial activity”, J. Serb. Chem. Soc., vol. 81, no. 8, pp. 851–858, Sep. 2016.

Issue

Vol. 81 No. 8 (2016)

Section

Organic Chemistry

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.