Microwave-assisted synthesis of 2,8-di(alkyl/aryl)-4,6-dichloro-2H,8H-pyrano[3,2-g]chromene-3,7-dicarbaldehydes and their antimicrobial activity

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Rupireddy Venkataramana
Venkata Ramana Reddy Chittireddy
Dongamanti Ashok
Kudle Karunakar Rao

Abstract

A series of 2,8-di(alkyl/aryl)-substituted bischromanone derivatives were synthesized in one pot from 4,6-diacetylresorcinol and aliphatic/aromatic aldehydes in the presence of pyrrolidine/piperidine under conventional heating and microwave irradiation. The 2,8-di(alkyl/aryl)-substituted bischromanones were converted into a new series of 4,6-dichloro-3,7-diformyl-2,8-di(alkyl/aryl)-substituted bischromenes using the Vilsmeier–Haack reagent. The structures of the compounds were established based on elemental analysis, IR, 1H-NMR, 13C-NMR and LC–MS spectral data. All the synthesized compounds were evaluated for their antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.

Article Details

How to Cite
[1]
R. Venkataramana, V. R. R. Chittireddy, D. Ashok, and K. K. Rao, “Microwave-assisted synthesis of 2,8-di(alkyl/aryl)-4,6-dichloro-2H,8H-pyrano[3,2-g]chromene-3,7-dicarbaldehydes and their antimicrobial activity”, J. Serb. Chem. Soc., vol. 84, no. 4, pp. 355-364, Apr. 2019.
Section
Organic Chemistry
Author Biographies

Venkata Ramana Reddy Chittireddy, Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad,Telangana,500 085

Professor of chemistry

 

Dongamanti Ashok, Department of Chemistry, Osmania University, Hyderabad, Telangana, 500 007

Professor of chemistry

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