A novel compound isolated from Sclerochloa dura has anti-inflammatory effects

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Syed Majid Bukhari
Astrid Jullumstrø Feuerherm
Hanna Maja Tunset
Stian Moe Isaksen
Mari Sæther
Thor Håkon Thvedt
Susana Villa Gonzalez
Rudolf Schmid
Anders Brunsvik
Erik Fuglset
Bojan Zlatković
Berit Johansen
Nebojša Simić


The activation of PLA2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, the non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. By using AA release assay as a guide for biological and anti-inflammatory activity, novel compound 1-O-(3-O-linolenoyl-6-deoxy-6-sulfo-α-D-glucopyranosyl)-glycerol (1) together with five known compounds isovitexin, byzantionoside B, tricin 4-O-(erythro-β-guaiacylglyceryl) ether 7-O-β-glucopyranoside, 1-O-feruloyl glycerol and tricin 7-glucoside were isolated from the methanol extract of the aerial parts of Sclerochloa dura using LC techniques (Sephadex LH-20 column chromatography, preparative HPLC and semi-preparative HPLC). All isolated compounds were identified using spectroscopic NMR spectroscopy and MS spectrometry. Novel compound (1) was found to be an effective inhibitor of AA release with an IC50 value of 0.09 ± 0.03 mg mL-1.


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How to Cite
S. M. Bukhari, “A novel compound isolated from Sclerochloa dura has anti-inflammatory effects”, J. Serb. Chem. Soc., vol. 81, no. 1, pp. 1–12, Feb. 2016.
Organic Chemistry
Author Biography

Bojan Zlatković, Department of Biology, Norwegian University of Sciences and Technology, 7491 Trondheim

Department of Biology, University of Niš, 18000 Niš