Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

Authors

  • Božidar Čobeljić Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia http://orcid.org/0000-0001-6335-0196
  • Marijana Živković University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia
  • Ivana Matić Institute of Oncology and Radiology of Serbia, Pasterova 14, Belgrade, Serbia
  • Irena Novaković University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia
  • Dušan Sladić Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia http://orcid.org/0000-0002-1000-9813
  • Katarina Anđelkovic Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia http://orcid.org/0000-0003-1178-8326
  • Natalija Krstić University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia

DOI:

https://doi.org/10.2298/10.2298/JSC201211083C

Keywords:

3-oxo-α, β-unsaturated steroids, hydrazones, square-planar complexes, cytotoxicity, antimicrobial activity

Abstract

In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D NMR and 2D NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that new steroidal thiosemicarbazone complexes were significantly less cytotoxic than corresponding steroidal thiosemicarbazones. Also, complexes show lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.

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Published

2020-12-14

How to Cite

[1]
B. Čobeljić, “Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones”, J. Serb. Chem. Soc., vol. 85, no. 5, p. -, Dec. 2020.

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Section

Inorganic Chemistry

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