December armageddon: Biothermodynamic analysis of rhinoviruses based on calculation of Gibbs energy of antigen-receptor binding and biosynthesis of rhinovirus particles
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Abstract
The subject of this research is a battle that is repeated every year and spreads epidemically on different territories, causing a large number of infected cases and casualties. Infections with rhinovirus are well known to the biomedical sciences. However, for deeper understanding of causes of rhinovirus disease and virus-host interaction (infection) it is necessary to understand it from the perspective of chemistry and biothermodynamics. This paper presents the empirical formulas, the driving forces of rhinovirus-host interactions, as well as a mechanistic model of virus-host interactions at the cell membrane and in the cytoplasm. Based on the described data, conclusions are presented about why 50% of infections of upper respiratory pathways are caused by rhinoviruses. For the first time, Gibbs energies of biosynthesis of virus particles of Rhinoviruses A2, B3 and C15, as well as Gibbs energy of binding of Rhinovirus A2 are presented, which are needed to understand the lifecycle of rhinoviruses.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution license 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
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Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Grant numbers 451-03-136/2025-03/200026
References
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