Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel Scientific paper

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Vesna Mišković-Stanković
Ana Janković
Svetlana G Grujić
Ivana Matić-Bujagić
Vesna Radojević
Maja Vukašinović-Sekulić
Vesna Kojić
Marija Djošić
Teodor Atanackovic


This study presents comparison of our recently formulated two com­part­mental model with General fractional derivative (GFD) and Korsmeyer–Peppas, Makoid–Banakar and Kopcha diffusion models. We have used our GFD model to study the release of gentamicin in poly (vinyl alcohol)/chit­osan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was pre­pared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solute­ion, at 37 °C. Different physicochemical (FTIR, SEM), mechanical and bio­logical (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined using a high-per­form­ance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial con­cen­tration of gentamicin in the hydrogel was monitored for the prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted to experimental data then other models, and enabled the determination of diffusion coefficient precisely for the entire time period.


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V. Mišković-Stanković, “Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel: Scientific paper”, J. Serb. Chem. Soc., vol. 89, no. 5, pp. 627–641, May 2024.
15 years of Professor Emeritus UNS

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