Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel

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Published: Feb 7, 2024
DOI: https://doi.org/10.2298/JSC231207010M
Keywords:
drug release diffusion pharmacokinetics cytotoxicity antibacterial activity mechanical properties

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Vesna Mišković-Stanković
Faculty of Ecology and Environmental Protection, University Union - Nikola Tesla, Cara Dusana 62-64, 11000 Belgrade, Serbia
https://orcid.org/0000-0001-6525-9820
Ana Janković
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
https://orcid.org/0000-0002-5605-3297
Svetlana G Grujić
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
https://orcid.org/0000-0003-4787-1391
Ivana Matić-Bujagić
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
https://orcid.org/0000-0001-8459-873X
Vesna Radojević
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
Maja Vukašinović-Sekulić
Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia
https://orcid.org/0000-0001-5374-5020
Vesna Kojić
Oncology Institute of Vojvodina, University of Novi Sad, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia
https://orcid.org/0000-0002-2399-0807
Marija Djošić
Institute for Technology of Nuclear and Other Mineral Raw Materials, Bulevar Franš d'Eperea 86, Belgrade, Serbia
https://orcid.org/0000-0002-0869-2182
Teodor Atanackovic
Faculty of Technical Sciences, University of Novi Sad, 21000 Novi Sad, Serbia
https://orcid.org/0000-0002-8714-1388

Abstract

This study presents comparison of our recently formulated two compartmental model with General fractional derivative (GFD) and Korsmeyer-Peppas, Makoid-Banakar and Kopcha diffusion models. We have used our GFD model to study the release of gentamicin in poly (vinyl alcohol)/chitosan/gentamicin (PVA/CHI/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/CHI/Gent hydrogel was prepared by physical cross linking of poly(vinyl alcohol)/chitosan dispersion using freezing-thawing method, and then was swollen for 48 h in gentamicin solution, at 37oC. Different physico-chemical (FTIR, SEM), mechanical and biological (cytotoxicity, antibacterial activity) properties have been determined. The concentration of released gentamicin was determined using a high-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). The ratio between concentration of released gentamicin and initial concentration of gentamicin in the hydrogel was monitored for the prolonged time period in order to obtain gentamicin release profile. It was proven that our novel diffusion GFD model better fitted with experimental data, and enabled the determination of diffusion coefficient precisely for the entire time period.

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How to Cite
[1]
V. Mišković-Stanković, “Diffusion models of gentamicin released in poly(vinyl alcohol)/chitosan hydrogel”, J. Serb. Chem. Soc., Feb. 2024.
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15 years of Professor Emeritus UNS
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Funding data

  • Horizon 2020 Framework Programme
    Grant numbers „Twinning to excel materials engineering for medical devices ExcellMater“ grant no. 952033, H2020-WIDESPREAD-2018-2020/H2020-WIDESPREAD-2020-5,2020-2023 (Ana Janković, Vesna Radojević)
  • Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
    Grant numbers Contracts No. 451-03-47/2023-01/200023 (Marija Djošić), 451-03-47/2023-01/200135 (Vesna Radojević, Maja Vukašinović-Sekulić, Svetlana Grujić, Ivana Matić-Bujagić), 451-03-47/2023-01/200287 (Ana Janković)

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